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To better understand the cellular uptake mechanisms of targeted nanocarriers we investigated the effects of free ligands, metabolic and endocytic inhibitors, and the modification of brain endothelial surface charge

Monday + Thursday) Total per week: 45 mg Aggressive loading (severe / acute injuries): 5 mg per injection , twice weekly = 10 mg/week Conservative loading (prevention / budget): 2.5 mg per injection , twice weekly = 5 mg/week Duration: 46 weeks Total peptide for standard loading: approximately 4050 mg (standard) or 80 mg (aggressive) TB-500 maintenance phase dosage Standard maintenance dose: 22.5 mg once weekly Reduced maintenance: 2 mg every 2 weeks (for long-term joint support) Duration: 48 weeks after loading

doi: 10.1111/cts.12694 58 HornungNStengaard-PedersenKEhrnroothEEllingsenTPoulsenJH

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